Neutrophil Extracellular Traps and Neutrophil Oxidized-Modified Proteins in Patients with Pneumonia
Background The mortality rate of community-acquired pneumonia (CAP) is high in adult patients. The highest mortality has been registered in patients in the older age group with a steady rise in the incidence of morbidity in younger people of working age. There is a need to focus research on the role of neutrophils in the pathogenesis of pneumonia as CAP largely determines the outcomes of the same. This research is aimed at evaluating the indices of neutrophils oxidized-modified proteins and oxidative stress in patients with CAP, depending on the severity, and comparison of the frequency of neutrophil extracellular traps responsible for causing the progress of pneumonia. Introduction The development of CAP is diverse among different patients. It is dependent on the etiology and the pathways of penetration of the microorganisms into the lungs. The evaluation of the changes in the metabolic and functional status of neutrophils could be one of the urgent areas of research, as their